Febuxostat is an antigout drug. It exhibits poor bioavailability of about 49% which is attributed to its poor solubility. Gout is a metabolic disorder characterized by elevated uric acid levels in the body, associated with painful, tophi and nephropathy. Spherical agglomerates were prepared by simple agglomeration technique. Agglomerates were prepared by using dimethylformamide, methanol and water as good solvent, bridging liquid and poor solvent, respectively. The polymer polyvinyl pyrrolidone (PVP K-30) were used in spherical agglomeration process. The pure drug and agglomerates were characterized by fourier transfer infra red spectroscopy. FTIR study indicated that there was no chemical change in the agglomerates of febuxostat. Micromeritic and dissolution studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. The spherical agglomerates exhibited excellent dissolution rate as compared to febuxostat. The agglomerates also exhibited higher micrometric properties which indicate good compressibility and packability characteristics.
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